PNOĒ, a Malden, Massachusetts-based startup, is preparing to launch its second-generation metabolic testing mask on October 1. The key change: users can now run the test themselves. Instead of requiring a trained operator, someone can put on the mask, press a button, and breathe for eight minutes to get measurements like VO₂ max, resting metabolic rate, and metabolic flexibility. The company says this self-serve model could expand its reach to fitness centers without dedicated staff and potentially even pharmacies.
The device is sold only to businesses, which then offer the test to their customers. Clients include Equinox, Four Seasons hotels, Red Bull, the NBA, Mount Sinai Health System, and Restore Hyper Wellness. Subscriptions range from $400 to more than $1,000 per month, covering hardware, software, training, and marketing materials. About 85% of PNOĒ's business comes from the U.S., which CEO Apostolos Atsalakis calls the most advanced market for longevity.
The company has raised roughly $22 million, including a recently closed $11 million round, with investors such as 50 Years and Google Maps co-founder Lars Rasmussen. PNOĒ is careful to position itself as a wellness device, not a medical one—it is not FDA-cleared and does not provide medical recommendations. Atsalakis says full diagnostic capabilities are "a couple of years away" at best. The new mask also addresses hygiene concerns: the electronics detach from the silicone mask and straps, so multiple users can share the hardware while keeping their own mask. The company is now expanding in Europe, Latin America, and Asia through partners.